21 results (0,16059 seconds)

Brand

Merchant

Price (EUR)

Reset filter

Products
From
Shops

Randomization Masking and Allocation Concealment

Understanding Artificial Intelligence

The Global Politics of Artificial Intelligence

Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development…. Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously. Jay Herson Johns Hopkins UniversityThe pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost time or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs precision medicine survival-endpoints dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons this book incorporates both statistical and clinical/medical perspectives. | Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

GBP 44.99
1

Statistical Techniques for Data Analysis

Deep and Shallow Machine Learning in Music and Audio

Mathematics for Engineers and Scientists

Mobile Crowdsensing

Mobile Crowdsensing

Mobile crowdsensing is a technology that allows large scale cost-effective sensing of the physical world. In mobile crowdsensing mobile personal devices such as smart phones or smart watches come equipped with a variety of sensors that can be leveraged to collect data related to environment transportation healthcare safety and so on. This book presents the first extensive coverage of mobile crowdsensing with examples and insights drawn from the authors’ extensive research on this topic as well as from the research and development of a growing community of researchers and practitioners working in this emerging field. Throughout the text the authors provide the reader with various examples of crowdsensing applications and the building blocks to creating the necessary infrastructure explore the related concepts of mobile sensing and crowdsourcing and examine security and privacy issues introduced by mobile crowdsensing platforms. Provides a comprehensive description of mobile crowdsensing a one-stop shop for all relevant issues pertaining to mobile crowdsensing including motivation applications design and implementation incentive mechanisms and reliability and privacy. Describes the design and implementations of mobile crowdsensing platforms of great interest for the readers working in research and industry to quickly implement and test their systems. Identifies potential issues in building such mobile crowdsensing applications to ensure their usability in real life and presents future directions in mobile crowdsensing by emphasizing the open problems that have to be addressed.

GBP 44.99
1

Elementary Number Theory

Introductory Statistics for the Health Sciences

Introductory Statistics for the Health Sciences

Introductory Statistics for the Health Sciences takes students on a journey to a wilderness where science explores the unknown providing students with a strong practical foundation in statistics. Using a color format throughout the book contains engaging figures that illustrate real data sets from published research. Examples come from many areas of the health sciences including medicine nursing pharmacy dentistry and physical therapy but are understandable to students in any field. The book can be used in a first-semester course in a health sciences program or in a service course for undergraduate students who plan to enter a health sciences program. The book begins by explaining the research context for statistics in the health sciences which provides students with a framework for understanding why they need statistics as well as a foundation for the remainder of the text. It emphasizes kinds of variables and their relationships throughout giving a substantive context for descriptive statistics graphs probability inferential statistics and interval estimation. The final chapter organizes the statistical procedures in a decision tree and leads students through a process of assessing research scenarios. Web ResourceThe authors have partnered with William Howard Beasley who created the illustrations in the book to offer all of the data sets graphs and graphing code in an online data repository via GitHub. A dedicated website gives information about the data sets and the authors’ electronic flashcards for iOS and Android devices. These flashcards help students learn new terms and concepts.

GBP 44.99
1

Disruptive Trends in Computer Aided Diagnosis

Disruptive Trends in Computer Aided Diagnosis

Disruptive Trends in Computer Aided Diagnosis collates novel techniques and methodologies in the domain of content based image classification and deep learning/machine learning techniques to design efficient computer aided diagnosis architecture. It is aimed to highlight new challenges and probable solutions in the domain of computer aided diagnosis to leverage balancing of sustainable ecology. The volume focuses on designing efficient algorithms for proposing CAD systems to mitigate the challenges of critical illnesses at an early stage. State-of-the-art novel methods are explored for envisaging automated diagnosis systems thereby overriding the limitations due to lack of training data sample annotation region of interest identification proper segmentation and so on. The assorted techniques addresses the challenges encountered in existing systems thereby facilitating accurate patient healthcare and diagnosis. Features: An integrated interdisciplinary approach to address complex computer aided diagnosis problems and limitations. Elucidates a rich summary of the state-of-the-art tools and techniques related to automated detection and diagnosis of life threatening diseases including pandemics. Machine learning and deep learning methodologies on evolving accurate and precise early detection and medical diagnosis systems. Information presented in an accessible way for students researchers and medical practitioners. The volume would come to the benefit of both post-graduate students and aspiring researchers in the field of medical informatics computer science and electronics and communication engineering. In addition the volume is also intended to serve as a guiding factor for the medical practitioners and radiologists in accurate diagnosis of diseases.

GBP 115.00
1

Social Computing and Virtual Communities

Social Computing and Virtual Communities

Growing more quickly than we can study or come to fully understand it social computing is much more than the next thing. Whether it is due more to technology-driven convenience or to the basic human need to find kindred connection online communication and communities are changing the way we live. Social Computing and Virtual Communities compiles contributions from international experts to offer the sort of multidisciplinary study that is required in any investigation of communities. Delving fully into theories and methods application areas and types of online social environments this book — Introduces several theories regarding online social interaction Provides a general overview of methodologies qualitative and quantitative for analyzing and evaluating virtual communities Makes an in-depth investigation into e-learning communities and the formation of social networks of learners Examines healthcare communities motivated by physical pain illness and burdensome symptoms Discusses intellectual property (IP) issues including those involving user-generated content Delves into the topic of online trust Introduces virtual communities in which users immerse themselves in a 3D virtual environment including MMORPG (massively multiplayer online role playing games) Presents an unusual community of older people of Chinese culture who perceive virtual communities as a place where old beliefs and traditional norms can be preserved Explores the rapid rise of social networking sites (SNS) Books of this kind are uncommon. This work not only provides case studies of different domains of virtual communities and different types of social technologies but also emphasizes theoretical and methodological aspects required to research and analyze such communities.

GBP 69.99
1

Estimands Estimators and Sensitivity Analysis in Clinical Trials

Estimands Estimators and Sensitivity Analysis in Clinical Trials

The concepts of estimands analyses (estimators) and sensitivity are interrelated. Therefore great need exists for an integrated approach to these topics. This book acts as a practical guide to developing and implementing statistical analysis plans by explaining fundamental concepts using accessible language providing technical details real-world examples and SAS and R code to implement analyses. The updated ICH guideline raises new analytic and cross-functional challenges for statisticians. Gaps between different communities have come to surface such as between causal inference and clinical trialists as well as among clinicians statisticians and regulators when it comes to communicating decision-making objectives assumptions and interpretations of evidence. This book lays out a path toward bridging some of these gaps. It offers¿ A common language and unifying framework along with the technical details and practical guidance to help statisticians meet the challenges¿ A thorough treatment of intercurrent events (ICEs) i. e. postrandomization events that confound interpretation of outcomes and five strategies for ICEs in ICH E9 (R1)¿ Details on how estimands integrated into a principled study development process lay a foundation for coherent specification of trial design conduct and analysis needed to overcome the issues caused by ICEs:¿ A perspective on the role of the intention-to-treat principle¿ Examples and case studies from various areas¿ Example code in SAS and R¿ A connection with causal inference¿ Implications and methods for analysis of longitudinal trials with missing dataTogether the authors have offered the readers their ample expertise in clinical trial design and analysis from an industrial and academic perspective. | Estimands Estimators and Sensitivity Analysis in Clinical Trials

GBP 39.99
1

Time Series A First Course with Bootstrap Starter

Time Series A First Course with Bootstrap Starter

Time Series: A First Course with Bootstrap Starter provides an introductory course on time series analysis that satisfies the triptych of (i) mathematical completeness (ii) computational illustration and implementation and (iii) conciseness and accessibility to upper-level undergraduate and M. S. students. Basic theoretical results are presented in a mathematically convincing way and the methods of data analysis are developed through examples and exercises parsed in R. A student with a basic course in mathematical statistics will learn both how to analyze time series and how to interpret the results. The book provides the foundation of time series methods including linear filters and a geometric approach to prediction. The important paradigm of ARMA models is studied in-depth as well as frequency domain methods. Entropy and other information theoretic notions are introduced with applications to time series modeling. The second half of the book focuses on statistical inference the fitting of time series models as well as computational facets of forecasting. Many time series of interest are nonlinear in which case classical inference methods can fail but bootstrap methods may come to the rescue. Distinctive features of the book are the emphasis on geometric notions and the frequency domain the discussion of entropy maximization and a thorough treatment of recent computer-intensive methods for time series such as subsampling and the bootstrap. There are more than 600 exercises half of which involve R coding and/or data analysis. Supplements include a website with 12 key data sets and all R code for the book's examples as well as the solutions to exercises. | Time Series A First Course with Bootstrap Starter

GBP 38.99
1

Introduction to Python Programming

Introduction to Python Programming

Introduction to Python Programming is written for students who are beginners in the field of computer programming. This book presents an intuitive approach to the concepts of Python Programming for students. This book differs from traditional texts not only in its philosophy but also in its overall focus level of activities development of topics and attention to programming details. The contents of the book are chosen with utmost care after analyzing the syllabus for Python course prescribed by various top universities in USA Europe and Asia. Since the prerequisite know-how varies significantly from student to student the book’s overall overture addresses the challenges of teaching and learning of students which is fine-tuned by the authors’ experience with large sections of students. This book uses natural language expressions instead of the traditional shortened words of the programming world. This book has been written with the goal to provide students with a textbook that can be easily understood and to make a connection between what students are learning and how they may apply that knowledge. Features of this book This book does not assume any previous programming experience although of course any exposure to other programming languages is useful This book introduces all of the key concepts of Python programming language with helpful illustrations Programming examples are presented in a clear and consistent manner Each line of code is numbered and explained in detail Use of f-strings throughout the book Hundreds of real-world examples are included and they come from fields such as entertainment sports music and environmental studies Students can periodically check their progress with in-chapter quizzes that appear in all chapters

GBP 160.00
1

Contemporary Abstract Algebra

Contemporary Abstract Algebra

Contemporary Abstract Algebra Tenth Edition For more than three decades this classic text has been widely appreciated by instructors and students alike. The book offers an enjoyable read and conveys and develops enthusiasm for the beauty of the topics presented. It is comprehensive lively and engaging. The author presents the concepts and methodologies of contemporary abstract algebra as used by working mathematicians computer scientists physicists and chemists. Students will learn how to do computations and to write proofs. A unique feature of the book are exercises that build the skill of generalizing a skill that students should develop but rarely do. Applications are included to illustrate the utility of the abstract concepts. Examples and exercises are the heart of the book. Examples elucidate the definitions theorems and proof techniques; exercises facilitate understanding provide insight and develop the ability to do proofs. The exercises often foreshadow definitions concepts and theorems to come. Changes for the tenth edition include new exercises new examples new quotes and a freshening of the discussion portions. The hallmark features of previous editions of the book are enhanced in this edition. These include: A good mixture of approximately 1900 computational and theoretical exercises including computer exercises that synthesize concepts from multiple chapters Approximately 300 worked-out examples from routine computations to the challenging Many applications from scientific and computing fields and everyday life Historical notes and biographies that spotlight people and events Motivational and humorous quotations Numerous connections to number theory and geometry While many partial solutions and sketches for the odd-numbered exercises appear in the book an Instructor’s Solutions Manual written by the author has comprehensive solutions for all exercises and some alternative solutions to develop a critical thought and deeper understanding. It is available from CRC Press only. The Student Solution Manual has comprehensive solutions for all odd-numbered exercises and many even-numbered exercises.

GBP 82.99
1

Bayesian Nonparametrics for Causal Inference and Missing Data

Bayesian Nonparametrics for Causal Inference and Missing Data

Bayesian Nonparametrics for Causal Inference and Missing Data provides an overview of flexible Bayesian nonparametric (BNP) methods for modeling joint or conditional distributions and functional relationships and their interplay with causal inference and missing data. This book emphasizes the importance of making untestable assumptions to identify estimands of interest such as missing at random assumption for missing data and unconfoundedness for causal inference in observational studies. Unlike parametric methods the BNP approach can account for possible violations of assumptions and minimize concerns about model misspecification. The overall strategy is to first specify BNP models for observed data and then to specify additional uncheckable assumptions to identify estimands of interest. The book is divided into three parts. Part I develops the key concepts in causal inference and missing data and reviews relevant concepts in Bayesian inference. Part II introduces the fundamental BNP tools required to address causal inference and missing data problems. Part III shows how the BNP approach can be applied in a variety of case studies. The datasets in the case studies come from electronic health records data survey data cohort studies and randomized clinical trials. Features • Thorough discussion of both BNP and its interplay with causal inference and missing data • How to use BNP and g-computation for causal inference and non-ignorable missingness • How to derive and calibrate sensitivity parameters to assess sensitivity to deviations from uncheckable causal and/or missingness assumptions • Detailed case studies illustrating the application of BNP methods to causal inference and missing data • R code and/or packages to implement BNP in causal inference and missing data problems The book is primarily aimed at researchers and graduate students from statistics and biostatistics. It will also serve as a useful practical reference for mathematically sophisticated epidemiologists and medical researchers.

GBP 90.00
1

Secret History The Story of Cryptology

Secret History The Story of Cryptology

The first edition of this award-winning book attracted a wide audience. This second edition is both a joy to read and a useful classroom tool. Unlike traditional textbooks it requires no mathematical prerequisites and can be read around the mathematics presented. If used as a textbook the mathematics can be prioritized with a book both students and instructors will enjoy reading. Secret History: The Story of Cryptology Second Edition incorporates new material concerning various eras in the long history of cryptology. Much has happened concerning the political aspects of cryptology since the first edition appeared. The still unfolding story is updated here. The first edition of this book contained chapters devoted to the cracking of German and Japanese systems during World War II. Now the other side of this cipher war is also told that is how the United States was able to come up with systems that were never broken. The text is in two parts. Part I presents classic cryptology from ancient times through World War II. Part II examines modern computer cryptology. With numerous real-world examples and extensive references the author skillfully balances the history with mathematical details providing readers with a sound foundation in this dynamic field. FEATURES Presents a chronological development of key concepts Includes the Vigenère cipher the one-time pad transposition ciphers Jefferson’s wheel cipher Playfair cipher ADFGX matrix encryption Enigma Purple and other classic methods Looks at the work of Claude Shannon the origin of the National Security Agency elliptic curve cryptography the Data Encryption Standard the Advanced Encryption Standard public-key cryptography and many other topics New chapters detail SIGABA and SIGSALY successful systems used during World War II for text and speech respectively Includes quantum cryptography and the impact of quantum computers | Secret History The Story of Cryptology

GBP 74.99
1

Abstract Algebra A First Course

Abstract Algebra A First Course

When a student of mathematics studies abstract algebra he or she inevitably faces questions in the vein of What is abstract algebra or What makes it abstract? Algebra in its broadest sense describes a way of thinking about classes of sets equipped with binary operations. In high school algebra a student explores properties of operations (+ − × and ÷) on real numbers. Abstract algebra studies properties of operations without specifying what types of number or object we work with. Any theorem established in the abstract context holds not only for real numbers but for every possible algebraic structure that has operations with the stated properties. This textbook intends to serve as a first course in abstract algebra. The selection of topics serves both of the common trends in such a course: a balanced introduction to groups rings and fields; or a course that primarily emphasizes group theory. The writing style is student-centered conscientiously motivating definitions and offering many illustrative examples. Various sections or sometimes just examples or exercises introduce applications to geometry number theory cryptography and many other areas. This book offers a unique feature in the lists of projects at the end of each section. the author does not view projects as just something extra or cute but rather an opportunity for a student to work on and demonstrate their potential for open-ended investigation. The projects ideas come in two flavors: investigative or expository. The investigative projects briefly present a topic and posed open-ended questions that invite the student to explore the topic asking and to trying to answer their own questions. Expository projects invite the student to explore a topic with algebraic content or pertain to a particular mathematician’s work through responsible research. The exercises challenge the student to prove new results using the theorems presented in the text. The student then becomes an active participant in the development of the field. | Abstract Algebra A First Course

GBP 99.99
1

Risks of Artificial Intelligence

Risks of Artificial Intelligence

If the intelligence of artificial systems were to surpass that of humans humanity would face significant risks. The time has come to consider these issues and this consideration must include progress in artificial intelligence (AI) as much as insights from AI theory. Featuring contributions from leading experts and thinkers in artificial intelligence Risks of Artificial Intelligence is the first volume of collected chapters dedicated to examining the risks of AI. The book evaluates predictions of the future of AI proposes ways to ensure that AI systems will be beneficial to humans and then critically evaluates such proposals. The book covers the latest research on the risks and future impacts of AI. It starts with an introduction to the problem of risk and the future of artificial intelligence followed by a discussion (Armstrong/Sokala/ÓhÉigeartaigh) on how predictions of its future have fared to date. Omohundro makes the point that even an innocuous artificial agent can easily turn into a serious threat for humans. T. Goertzel explains how to succeed in the design of artificial agents. But will these be a threat for humanity or a useful tool? Ways to assure beneficial outcomes through ‘machine ethics’ and ‘utility functions’ are discussed by Brundage and Yampolskiy. B. Goertzel and Potapov/Rodionov propose ‘learning’ and ‘empathy’ as paths towards safer AI while Kornai explains how the impact of AI may be bounded. Sandberg explains the implications of human-like AI via the technique of brain emulation. Dewey discusses strategies to deal with the ‘fast takeoff’ of artificial intelligence and finally Bishop explains why there is no need to worry because computers will remain in a state of ‘artificial stupidity’. Sharing insights from leading thinkers in artificial intelligence this book provides you with an expert-level perspective of what is on the horizon for AI whether it will be a threat for humanity and how we might counteract this threat.

GBP 44.99
1

An Introduction to Analysis

An Introduction to Analysis

The third edition of this widely popular textbook is authored by a master teacher. This book provides a mathematically rigorous introduction to analysis of real­valued functions of one variable. This intuitive student-friendly text is written in a manner that will help to ease the transition from primarily computational to primarily theoretical mathematics. The material is presented clearly and as intuitive as possible while maintaining mathematical integrity. The author supplies the ideas of the proof and leaves the write-up as an exercise. The text also states why a step in a proof is the reasonable thing to do and which techniques are recurrent. Examples while no substitute for a proof are a valuable tool in helping to develop intuition and are an important feature of this text. Examples can also provide a vivid reminder that what one hopes might be true is not always true. Features of the Third Edition: Begins with a discussion of the axioms of the real number system. The limit is introduced via sequences. Examples motivate what is to come highlight the need for hypothesis in a theorem and make abstract ideas more concrete. A new section on the Cantor set and the Cantor function. Additional material on connectedness. Exercises range in difficulty from the routine getting your feet wet types of problems to the moderately challenging problems. Topology of the real number system is developed to obtain the familiar properties of continuous functions. Some exercises are devoted to the construction of counterexamples. The author presents the material to make the subject understandable and perhaps exciting to those who are beginning their study of abstract mathematics. Table of Contents Preface Introduction The Real Number System Sequences of Real Numbers Topology of the Real Numbers Continuous Functions Differentiation Integration Series of Real Numbers Sequences and Series of Functions Fourier Series Bibliography Hints and Answers to Selected Exercises Index Biography James R. Kirkwood holds a Ph. D. from University of Virginia. He has authored fifteen published mathematics textbooks on various topics including calculus real analysis mathematical biology and mathematical physics. His original research was in mathematical physics and he co-authored the seminal paper in a topic now called Kirkwood-Thomas Theory in mathematical physics. During the summer he teaches real analysis to entering graduate students at the University of Virginia. He has been awarded several National Science Foundation grants. His texts Elementary Linear Algebra Linear Algebra and Markov Processes are also published by CRC Press. | An Introduction to Analysis

GBP 82.99
1