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Translational Bioinformatics for Therapeutic Development - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Translational Bioinformatics for Therapeutic Development - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume introduces Translational Bioinformatics as it relates to therapeutic development, and addresses the techniques needed to effectively translate large data sets to relevant biological networks. Chapters detail clinical informatics infrastructure, and leverage pathology, immunology, pharmacology, genomic, proteomic, and metabolomic informatics approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Translational Bioinformatics for Therapeutic Development: Methods and Protocols aims to ensure success in the study of Translational Bioinformatics.

DKK 967.00
1

Arabidopsis Protocols - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Arabidopsis Protocols - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This fourth edition compiles the most recent methodologies developed to exploit the Arabidopsis genome. Chapters detail access to public resources, to genetic, cell biology, biochemical and physiological techniques, and sections on genome, transcriptome, proteome, metabolome and other whole-system approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Arabidopsis Protocols, Fourth Edition aims to ensure successful results in the further study of this vital field.

DKK 967.00
1

Patch Clamp Electrophysiology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Patch Clamp Electrophysiology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume describes a range of standard and novel methodological approaches used to probe ion channel function across different modalities. Chapters guide readers through methods and protocols from an introduction to the decades old patch clamp method for the ion channel neophyte to more complex, recent protocol advances, such as optogenetics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Patch Clamp Electrophysiology: Methods and Protocols aims to be a reference guide for current and future ion channel physiologists.

DKK 967.00
1

Detection of Cell Death Mechanisms - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Detection of Cell Death Mechanisms - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides detailed protocols for the performance, analysis, and troubleshooting of in vitro and in vivo experiments related to programmed cell death. Chapters compile conventional techniques such as western blot and qPCR and state-of-the art transmission electron microscopy and real-time multiplexed imaging assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Detection of Cell Death Mechanisms: Methods and Protocols aims to ensure seamless execution of protocols on specific cell death type.

DKK 967.00
1

RNA Remodeling Proteins - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

RNA Remodeling Proteins - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides the most current methods to study RNA remodeling proteins. Chapters detail methods, ranging from basic to complex, procedures to identify RNA remodeling proteins and their cofactors, physiological RNA targets and biological functions, and complex molecular mechanisms of action using purified components. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA Remodeling Proteins: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

DKK 967.00
1

Computational Methods in Synthetic Biology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Computational Methods in Synthetic Biology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This second edition book provides complete coverage of the computational approaches currently used in Synthetic Biology. New chapters detail computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Computational Methods in Synthetic Biology, Second Edition aims to feature a broad overview of the research areas that can be met in the area of in silico Synthetic Biology.

DKK 967.00
1

Forensic Ethics and the Expert Witness - Richard Martinez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Forensic Ethics and the Expert Witness - Richard Martinez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This book details possible ethical situations and pitfalls that forensic psychiatric experts would commonly encounter when making a court testimony. Richly illustrated with cases from medicine, psychiatry, and law, this elegantly written volume examines the common moral ground that links these usually separate domains, and relates forensic ethics to larger concepts of morality and justice.

DKK 618.00
1

cryoEM - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

cryoEM - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume details the most up-to-date cryo-EM techniques from leading researchers. Chapters are organized into four parts with emphasis on electron cryotomography, single particle analysis, and the crystal based cryo-EM methods of 2D electron crystallography, and MicroED for the study of 3D crystals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CryoEM: Methods and Protocols aims to serve as an excellent resource on cryo-EM and can serve as the foundation for new researchers to this growing field in structural biology.

DKK 800.00
1

Artificial Neural Networks - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Artificial Neural Networks - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume presents examples of how Artificial Neural Networks (ANNs) are applied in biological sciences and related areas. Chapters cover a wide variety of topics, including the analysis of intracellular sorting information, prediction of the behavior of bacterial communities, biometric authentication, studies of Tuberculosis, gene signatures in breast cancer classification, the use of mass spectrometry in metabolite identification, visual navigation, and computer diagnosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Artificial Neural Networks: Third Edition should be of value to all scientists interested in the hands-on application of ANNs in the biosciences.

DKK 967.00
1

Explorations in Learning and the Brain - Annemarie Boschloo - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Explorations in Learning and the Brain - Annemarie Boschloo - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume presents a short review study of the potential relationships between cognitive neuroscience and educational science. Conducted by order of the Dutch Programme Council for Educational Research of the Netherlands Organization for Scienti c Research (NWO; cf. the American NSF), the review aims to identify: (1) how educational principles, mechanisms, and theories could be extended or re ned based on ndings from cognitive neuroscience, and (2) which neuroscience prin- ples, mechanisms, or theories may have implications for educational research and could lead to new interdisciplinary research ventures. The contents should be seen as the outcome of the ''Explorations in Learning and the Brain'' project. In this project, we started with a ''quick scan'' of the lite- ture that formed the input for an expert workshop that was held in Amsterdam on March 10-11,2008. This expert workshopidenti ed additional relevant themesand issues that helped us to update the ''quick scan'' into this nal document. In this way the input from the participants of the expert workshop (listed in Appendix A) has greatly in uenced the present text. We are therefore grateful to the participants for their scholarly and enthusiastic contributions. The content of the current volume, however, is the full responsibility of the authors.

DKK 434.00
1

Mitochondrial Medicine - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Mitochondrial Medicine - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

DKK 1089.00
1

Statistical Science in the Courtroom - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Statistical Science in the Courtroom - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Expert testimony relying on scientific and other specialized evidence has come under increased scrutiny by the legal system. A trilogy of recent U.S. Supreme Court cases has assigned judges the task of assessing the relevance and reliability of proposed expert testimony. In conjunction with the Federal judiciary, the American Association for the Advancement of Science has initiated a project to provide judges indicating a need with their own expert. This concern with the proper interpretation of scientific evidence, especially that of a probabilistic nature, has also occurred in England, Australia and in several European countries. Statistical Science in the Courtroom is a collection of articles written by statisticians and legal scholars who have been concerned with problems arising in the use of statistical evidence. A number of articles describe DNA evidence and the difficulties of properly calculating the probability that a random individual''s profile would "match" that of the evidence as well as the proper way to intrepret the result. In addition to the technical issues, several authors tell about their experiences in court. A few have become disenchanted with their involvement and describe the events that led them to devote less time to this application. Other articles describe the role of statistical evidence in cases concerning discrimination against minorities, product liability, environmental regulation, the appropriateness and fairness of sentences and how being involved in legal statistics has raised interesting statistical problems requiring further research.

DKK 426.00
1

Primary Care Medicine for Psychiatrists - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Primary Care Medicine for Psychiatrists - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Directly addressing the specific needs of psychiatrists and other mental health professionals, this pioneering book is a first response guide to medical, surgical, neurological, and special psychiatric problems that may be encountered in clinical practice. The text features both the expert contributions of medical specialists and the guidance of board-certified psychiatrists. Quick and practical, it may be searched either by specific diseases or symptoms. Internal medicine, neurology, chronic pain, surgery, pediatrics, and preventive health care are all addressed.

DKK 731.00
1

Rapid and Practical Interpretation of Urodynamics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Rapid and Practical Interpretation of Urodynamics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides practitioners with a practical, easy to read, well organized approach to the performance and analysis of urodynamics in order to optimize their usage clinically. Chapters are structured around specific types of patterns seen on urodynamic tracings. These urodynamic tracings are annotated and fully interpreted by the authors. Multiple examples of each type of tracing are provided with expert commentary. The expert commentary expands on the potential clinical significance of the tracing, provides a differential diagnosis, and, where appropriate, discusses its importance diagnostically, prognostically and the implications for clinical management. The text contains chapters on virtually all the relevant urodynamic findings and clinical conditions seen in practice, including lower urinary tract conditions in both adults and children, neurogenic and non-neurogenic dysfunction, and other commonly seen conditions such as lower urinary tract obstruction, vaginal prolapse, and detrusor overactivity. The material is also presented in a practical manner, with special consideration to the latest national and international guidelines. Written by authorities in the field, Rapid and Practical Interpretation of Urodynamics is a valuable resource that fills a key gap by providing a systematic method of interpretation of urodynamic tracings in an easy to understand textbook that will benefit urologic trainees and experienced urologists alike.

DKK 699.00
1

Urolithiasis - Michael E. Moran - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Urolithiasis - Michael E. Moran - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.

DKK 877.00
1

The Hundred Greatest Stars - James B. Kaler - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Hundred Greatest Stars - James B. Kaler - Bog - Springer-Verlag New York Inc. - Plusbog.dk

While there are guides to the visible sky, this is the first book to encompass the most important stars known in the universe at a level accessible to the layperson. The noted astronomer James Kaler takes us on a tour of the 100 most interesting stars, describing their characteristics and importance in words and vivid pictures. James B. Kaler is an internationally recognized expert on stars and their formation. A professor of astronomy at the University of Illinois, he is the author of "Stars and Their Spectra" (Cambridge), "Stars" (Freeman/Scientific American Library), "Cosmic Clouds" (Freeman/Scientific American Library), and numerous articles for popular and professional astronomy magazines.

DKK 222.00
1

Microarray Data Analysis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Microarray Data Analysis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This meticulous book explores the leading methodologies, techniques, and tools for microarray data analysis, given the difficulty of harnessing the enormous amount of data. The book includes examples and code in R, requiring only an introductory computer science understanding, and the structure and the presentation of the chapters make it suitable for use in bioinformatics courses. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key detail and expert implementation advice that ensures successful results and reproducibility. Authoritative and practical, Microarray Data Analysis is an ideal guide for students or researchers who need to learn the main research topics and practitioners who continue to work with microarray datasets.

DKK 986.00
1

ELISA - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

ELISA - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides an understanding of how an immunoassay works, detailing the strengths, weaknesses, pitfalls. Chapters guide readers on how and when to appropriately utilize this powerful tool, examples of where the ELISA or similar immunoassay formats are currently being used, and newer techniques that may have a significant impact on future applications. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, ELISA: Methods and Protocols is a valuable resource for both novice and expert scientists in this developing field.

DKK 967.00
1

Neuromuscular Imaging - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Neuromuscular Imaging - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Neuromuscular imaging has increasingly become an important tool in the detection and diagnosis of inherited and acquired neuromuscular disease. This book is a groundbreaking radiological and neurological overview of current methods and applications of imaging—including aspects of neuroimaging and musculoskeletal imaging—in patients with inherited, metabolic, and inflammatory muscle diseases. Imaging features are discussed in the context of clincial presentation, histopathology, therapeutic options and differential diagnosis. World leading expert contributors give a comprehensive and didactic review of neuromuscular disorders and available imaging modalities, each illustrated with numerous figures. Topics discussed include: -Modalities such as ultrasound, CT and MRI -Muscle anatomy and physiology -Clinical applications in hereditary and acquired myopathies -Clinical applications in motor neuron disorders and peripheral nerve imaging

DKK 861.00
1

Experimental Models of Cardiovascular Diseases - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Experimental Models of Cardiovascular Diseases - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This second edition provides new and updated methods for establishing reliable and reproducible experimental models of cardiovascular diseases. Chapters detail practical protocols from expert laboratories focusing on cardiovascular research, that would be critical in exploring novel discoveries in cardiac biology, and the development of effective therapeutic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Experimental Models of Cardiovascular Diseases: Methods and Protocols, Second Edition aims to provide detailed and practical protocols that will be valuable tools for researchers in cardiology to conduct their research.

DKK 1197.00
1

Phase-Separated Biomolecular Condensates - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Phase-Separated Biomolecular Condensates - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides readers with a broad collection of theoretical, computational, and experimental methods to quantitatively study the properties of phase-separate biomolecular condensates in diverse systems. The chapters in this book cover topics such as theoretical and computational methods; methods for in vitro characterization of biomolecular condensates; and techniques that enable in-cell characterization of biomolecular condensates. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Phase-Separated Biomolecular Condensates: Methods and Protocols is a valuable resource that helps researchers learn and use established methods to study both biophysical properties and biological functions of biomolecular condensates.

DKK 901.00
1

Inflammatory Dermatopathology - Steven D. Billings - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Inflammatory Dermatopathology - Steven D. Billings - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Inflammatory Dermatopathology: A Pathologist''s Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist''s Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.

DKK 960.00
1

Endocrinology of Pregnancy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Endocrinology of Pregnancy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

DKK 901.00
1

Volume Microscopy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Volume Microscopy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume discusses different approaches to workflows for large volume electron microscopy - from preparation of samples to their imaging in a variety of microscopes - in some cases also applying correlative techniques. The chapters in this book cover topics such as correlative super resolution and electron microscopy to detect molecules in their native cellular context; low-threshold access to serial section arrays; improving serial blockface SEM by focal charge compensation; FIBSEM analysis of interfaces between hard technical devices and soft neuronal tissue; and image processing for volume electron microscopy. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and authoritative, Volume Microscopy: Multiscale Imaging with Photons, Electrons, and Ions is a valuable resource for novice and expert scientists interested in learning more about this evolving field.

DKK 884.00
1