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Planet Mercury - From Pale Pink Dot to Dynamic World - Bog af David A. Rothery - Hardback

Sigma 7 - Colin Burgess - Bog - Springer International Publishing AG - Plusbog.dk

Metal Response in Cupriavidus metallidurans - Guy Vandenbussche - Bog - Springer International Publishing AG - Plusbog.dk

Metal Response in Cupriavidus metallidurans - Guy Vandenbussche - Bog - Springer International Publishing AG - Plusbog.dk

This book is the second volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this second volume, the structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury. In addition, the first volume sketches the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. It provides a detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands.

DKK 416.00
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Historical Diseases from a Modern Perspective - James A. Shaw - Bog - Springer International Publishing AG - Plusbog.dk

Historical Diseases from a Modern Perspective - James A. Shaw - Bog - Springer International Publishing AG - Plusbog.dk

Historical Diseases from a Modern Perspective: The American Experience is a must read for any student of history or fan of historical novels. Every disease section contains fascinating historical insights relevant to the American experience, including how the 1900 outbreak of plague in San Franciso was contained, why the flow of the Chicago River was reversed, why “chicken pox parties” were once common, how the scourge of yellow fever was abated, and why poor southerners were once considered lazy and shiftless. Those readers interested in military history will learn how smallpox impacted troop strength in the Revolutionary War, dysentery in the Civil War, influenza in WWI, malaria in WWII, and sexually transmitted diseases across all wars. The social history of alcohol and opioid use is outlined as is the pre-antibiotic treatment of syphilis and gonorrhea, giving rise to the quip, “A night with Venus and a lifetime with mercury,” and the nickname “clap.” The use of anthrax as a tool of bioterrorism, the debilitating effects of scurvy, and the horror of leprosy are all discussed, along with multiple other diseases of historical interest. The text begins by outlining historical theories of disease causation, prevention and cure, to provide a contextual understanding for the reader. The ensuing chapters describe how historical diseases acquired their traditional monikers (Spanish flu, ship fever, ague, blue death, breakbone fever, scarlet fever, etc.) and how they were treated before the era of modern medicine. Emphasis is placed on the impact of disease outbreaks on society and how the understanding, treatment, and prevention of these diseases developed over time. The threat of historical disease reemergence due to waning vaccine immunities, vaccine hesitancy, antibiotic resistance and climate change is noted as a subtext throughout the book – a peril of global concern at this time. The book covers a large array of historical diseases, grouped for clarity and understanding within the broad categories of contagious diseases, vector-borne/zoonotic diseases, fecal-oral diseases, sexually transmitted diseases, substance use disorders, parasitic diseases, nutritional diseases, fungal diseases, and soil-related bacterial diseases.

DKK 301.00
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